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MACRODOX 200 is a water-soluble powder for oral use, which is composed of doxycycline hydrochloride and tylosin tartrate. This combination of two antibacterial components due to the fact that both belong to the same antibiotic group: “Fast-acting antibiotics with bacteriostatic action type, in which high concentrations of bactericidal effect.” The preparation has a broad spectrum of action and particularly effective in infections caused by Chlamydia, Mycoplasma and Rickettsia spp. The potentiating action of ingredients gives this effect. Synergies doxycycline and tylosin is a similar mechanism of action. Both components disrupt the synthesis of proteins of microbial cells. Thus doxycycline acts on receptors of 30 S ribosomal group blocking attachment amino acetyl tRNA to the acceptor spot to prevent the addition of new amino acids to a peptide chain and thus anticipates the protein synthesis. A mechanism of action is based on the tylosin 50 S ribosomal binding group of microbial cells, resulting in impaired the translocation of peptides and protein synthesis inhibition. This both-way mechanism at different parts of the RNA of microbial cells reinforces the antimicrobial effect of the medicine.
Poultry for medical and preventive purposes;
Pigs for medical purposes in the respiratory and gastrointestinal diseases of bacterial etiology, including pasteurellosis, mycoplasmosis, colibacillosis, salmonellosis, dysentery, enzootic pneumonia caused by Staphylococcus spp., Streptococcus spp., Bac. аntracis, Clostridium spp., Listeria, Actinomyces spp., Klebsiella spp., Shigella spp., Yersinia spp., Bordetella, Campylobacter, E. coli, Haemophylus, Pasteurella, Salmonella, Staphilococcus spp., Streptococcus spp., Treponema spp., атакже Chlamydia, Mycoplasma и Rickettsia spp.
Dosage: orally with drinking water or mixed with feed at a dose of 500-1000 gr of product per 1000 l of water is equivalent to:
Poultry: 0,5-1 gr of oral powder per 10 kg of poultry body weight for a period of 3-5 days;
Pigs: 1 gr of oral powder per 10-15 kg of pig body weight for a period of 3-5 days;
Poultry: 7 days
Pigs: 8 days